Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer
نویسندگان
چکیده
Metformin is a widely prescribed hypoglycemic drug. Many studies have shown its anti-cancer properties. In the present study, we aimed to explore effect of metformin on breast cancer and clarify underlying mechanism. Our results showed that induced ferroptosis in MDA-MB-231 cells through upregulating miR-324-3p expression. Overexpression inhibited cell viability. inhibitor promoted Further was mediated by directly targeting glutathione peroxidase 4 (GPX4). bound 3?-UTR GPX4 led downregulation GPX4. vivo xenograft model mice. study suggested promotes miR-324-3p/GPX4 axis. could act as potential agent induction ferroptosis.
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2021
ISSN: ['1745-7270', '1672-9145']
DOI: https://doi.org/10.1093/abbs/gmaa180